Journal article
BRCA2 carriers with male breast cancer show elevated tumour methylation
S Deb, KL Gorringe, JMB Pang, DJ Byrne, EA Takano, CF Investigators, A Dobrovic, SB Fox
BMC Cancer | BIOMED CENTRAL LTD | Published : 2017
Abstract
Background: Male breast cancer (MBC) represents a poorly characterised group of tumours, the management of which is largely based on practices established for female breast cancer. However, recent studies demonstrate biological and molecular differences likely to impact on tumour behaviour and therefore patient outcome. The aim of this study was to investigate methylation of a panel of commonly methylated breast cancer genes in familial MBCs. Methods: 60 tumours from 3 BRCA1 and 25 BRCA2 male mutation carriers and 32 males from BRCAX families were assessed for promoter methylation by methylation-sensitive high resolution melting in a panel of 10 genes (RASSF1A, TWIST1, APC, WIF1, MAL, RARβ, ..
View full abstractGrants
Funding Acknowledgements
kConFab is supported by grants from the National Breast Cancer Foundation, the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia. Siddhartha Deb received a postgraduate scholarship from the NHMRC. Funding from the National Breast Cancer Foundation (AD), Victorian Cancer Agency (KG), the Cancer Council of Victoria (AD) and Cancer Australia also supported this study.